×
Entrez Id: 7428
Gene Symbol: VHL
VHL
Renal Cell Carcinoma
0.700
AlteredExpression
LHGDN
VHL expression in renal cell carcinoma sensitizes to bortezomib (PS-341) through an NF-kappaB-dependent mechanism.
15608669 2005
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Renal Cell Carcinoma
0.700
AlteredExpression
LHGDN
[Kidney tumors].
17593340 2007
×
Entrez Id: 7428
Gene Symbol: VHL
VHL
Renal Cell Carcinoma
0.700
AlteredExpression
LHGDN
Intragenic mutation of the VHL gene was found exclusively in clear-cell or variant-type RCC s at a frequency of 51% (104/202).
11921283 2002
×
Entrez Id: 7428
Gene Symbol: VHL
VHL
Renal Cell Carcinoma
0.700
AlteredExpression
LHGDN
The von Hippel-Lindau tumor suppressor gene product represses oncogenic beta-catenin signaling in renal carcinoma cells.
16983094 2006
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Renal Cell Carcinoma
0.700
AlteredExpression
LHGDN
We concluded that a strong expression of PTEN in renal cell cancer did not block the PI3K-mediated phosphorylation of Akt in the tumour specimens analysed.
18425369 2008
×
Entrez Id: 7428
Gene Symbol: VHL
VHL
Renal Cell Carcinoma
0.700
AlteredExpression
LHGDN
Finally, immunohistochemical staining of Cyr61/CCN1 and CTGF/CCN2 in RCC tissue samples showed that increased expression of these proteins correlates with the loss of VHL protein expression.
18212329 2008
×
Entrez Id: 7428
Gene Symbol: VHL
VHL
Renal Cell Carcinoma
0.700
AlteredExpression
LHGDN
Loss of expression of von Hippel-Lindau tumor suppressor protein associated with improved survival in patients with early-stage clear cell renal cell carcinoma.
15893810 2005
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Renal Cell Carcinoma
0.700
AlteredExpression
LHGDN
Renal tumours (renal cell carcinomas and oncocytomas) express PTEN protein predominantly in the cytoplasm.
17886097 2007
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Renal Cell Carcinoma
0.700
AlteredExpression
LHGDN
Expression of PTEN in 40 cases of renal cell carcinoma were different, 12.5% were negative, 17.5% were weak positive, and 70% were strong positive.
12452054 2002
×
Entrez Id: 2034
Gene Symbol: EPAS1
EPAS1
Renal Cell Carcinoma
0.700
AlteredExpression
LHGDN
Renal cancer cells lacking hypoxia inducible factor (HIF)-1alpha expression maintain vascular endothelial growth factor expression through HIF-2alpha.
16920734 2007
×
Entrez Id: 7428
Gene Symbol: VHL
VHL
Renal Cell Carcinoma
0.700
AlteredExpression
LHGDN
von Hippel-Lindau protein-mediated repression of tumor necrosis factor alpha translation revealed through use of cDNA arrays.
12640117 2003
×
Entrez Id: 4968
Gene Symbol: OGG1
OGG1
Renal Cell Carcinoma
0.620
AlteredExpression
LHGDN
Concomitant loss of mitochondria and the DNA repair protein hOGG1 in clear cell carcinoma of the kidney.
14663360 2003
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
Renal Cell Carcinoma
0.600
AlteredExpression
LHGDN
COX-2 protein in RCC was not altered in comparison with normal renal tissue.15569051 2004
×
Entrez Id: 7030
Gene Symbol: TFE3
TFE3
Renal Cell Carcinoma
0.500
AlteredExpression
LHGDN
Renal cell carcinoma associated with TFE3 gene fusion in an elderly woman.17905124 2007
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Renal Cell Carcinoma
0.500
AlteredExpression
LHGDN
Taken together, our findings support a role for pVHL in elevating p53 expression, implicate HuR in enhancing VHL-mediated p53 translation, and suggest that VHL-mediated p53 upregulation may contribute to pVHL's tumor suppressive functions in renal cell carcinoma .
14517280 2003
×
Entrez Id: 3855
Gene Symbol: KRT7
KRT7
Renal Cell Carcinoma
0.400
AlteredExpression
LHGDN
Association of cytokeratin 7 and 19 expression with genomic stability and favorable prognosis in clear cell renal cell cancer.
18478571 2008
×
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
Renal Cell Carcinoma
0.400
AlteredExpression
LHGDN
Low adiponectin levels are associated with renal cell carcinoma: a case-control study.
17205522 2007
×
Entrez Id: 3569
Gene Symbol: IL6
IL6
Renal Cell Carcinoma
0.400
AlteredExpression
LHGDN
In conclusion, this spliced form of IL-6 mRNA detected in RCC encodes for a truncated IL-6 with IL-6 antagonist properties.
15665272 2005
×
Entrez Id: 3569
Gene Symbol: IL6
IL6
Renal Cell Carcinoma
0.400
AlteredExpression
LHGDN
Here we demonstrate that NEU3 mRNA level are increased in renal cell carcinomas (RCC s) compared with adjacent non-tumor tissues, significantly correlating with elevation of interleukin-6 (IL-6 ), a pleiotropic cytokine that has been implicated in immune responses and pathogenesis of several cancers, including RCC s.
16428383 2006
×
Entrez Id: 3855
Gene Symbol: KRT7
KRT7
Renal Cell Carcinoma
0.400
AlteredExpression
LHGDN
Cytokeratin 7 was rarely seen in clear cell renal cell carcinomas , type 2 papillary renal cell carcinomas , and oncocytomas, but was found in the majority of type 1 papillary renal cell carcinomas (97.1%) and chromophobe renal cell carcinomas (88%).15502805 2005
×
Entrez Id: 79444
Gene Symbol: BIRC7
BIRC7
Renal Cell Carcinoma
0.370
AlteredExpression
LHGDN
Livin protein in renal cell carcinoma samples exhibited cytoplasmic and/or nuclear staining.17968430 2007
×
Entrez Id: 79444
Gene Symbol: BIRC7
BIRC7
Renal Cell Carcinoma
0.370
AlteredExpression
LHGDN
Expression of the apoptosis inhibitor livin in renal cell carcinomas: correlations with pathology and outcome.
17519534 2007
×
Entrez Id: 332
Gene Symbol: BIRC5
BIRC5
Renal Cell Carcinoma
0.340
AlteredExpression
LHGDN
Distinct in vivo expression patterns of survivin splice variants in renal cell carcinomas.
12115583 2002
×
Entrez Id: 332
Gene Symbol: BIRC5
BIRC5
Renal Cell Carcinoma
0.340
AlteredExpression
LHGDN
Survivin associates with cell proliferation in renal cancer cells: regulation of survivin expression by insulin-like growth factor-1, interferon-gamma and a novel NF-kappaB inhibitor.
16525632 2006
×
Entrez Id: 3315
Gene Symbol: HSPB1
HSPB1
Renal Cell Carcinoma
0.320
AlteredExpression
LHGDN
Two isoforms were not detected using anti-Ser82 phosphorylated HSP27 antibody, neither in normal nor in RCC samples.
15274119 2004